2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphodiesterase (PDE)
  5. Phosphodiesterase (PDE) Modulator

Phosphodiesterase (PDE) Modulator

Phosphodiesterase (PDE) Isoform Comparison

Phosphodiesterase (PDE) Modulators (4):

Cat. No. Product Name Effect Purity
  • HY-12812
    Autotaxin modulator 1
    		Modulator 98.93%
    Autotaxin modulator 1 is an autotaxin (ATX) enzyme inhibitor, extracted from patent WO 2014018881 A1, Compound Example 12b. Autotaxin modulator 1 is expected to be useful for researching demyelination due to injury or disease, as well as for researching proliferative disorders such as cancer.
  • HY-136350
    BRD9500
    		Modulator 99.46%
    BRD9500 is an orally active phosphodiesterases 3 (PDE3) inhibitor with IC50s of 10 and 27 nM for PDE3A and PDE3B, respectively. Antitumor activity.
  • HY-103035
    BIO-32546
    		Modulator 99.05%
    BIO-32546 (example 12b, S-isomer) is an autotaxin (ATX) modulator (IC50: 1 nM), extracted from the patent US20170158687A1.
  • HY-N10149
    Nauclefine
    		Modulator
    Nauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a PDE3A modulator to induce cancer cell apoptosis through a PDE3A-SLFN12-dependent death pathway.